Inhibition of glutathione S-transferase by bile acids

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Inhibition of glutathione S-transferase by bile acids.

The effects of bile acids on the detoxification of compounds by glutathione conjugation have been investigated. Bile acids were found to inhibit the total soluble-fraction glutathione S-transferase activity from rat liver, as assayed with four different acceptor substrates. Dihydroxy bile acids were more inhibitory than trihydroxy bile acids, and conjugated bile acids were generally less inhibi...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1981

ISSN: 0264-6021

DOI: 10.1042/bj1970321